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[Nle4,DPhe7] a-MSH, amide;Melanotan Ⅰ

Name
[Nle4,DPhe7] a-MSH, amide;Melanotan Ⅰ
Molecular structural formula
Purity
≥95%
CAS Number
75921-69-6
Formula
C78H111N21O19
MW
1646.9
Target
Melanocortin Receptor
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Sequence Shortening
Ac-SYS-{Nle}-EH-{D-Phe}-RWGKPV-NH2
InChIKey
UAHFGYDRQSXQEB-PWPYQVNISA-N
Solubility in water
≥ 50 mg/mL
References
[1]. Langan EA, et al. Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'? Br J Dermatol. 2010 Sep;163(3):451-5. [2]. Reid C, et al. Atypical melanocytic naevi following melanotan injection. Ir Med J. 2013 May;106(5):148-9. [3]. Bhardwaj R, et al. Controlled-release delivery system for the alpha-MSH analog melanotan-I using poloxamer 407. J Pharm Sci. 1996 Sep;85(9):915-9.
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Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for sunlight-induced skin cancers research.